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ea0092ps2-11-03 | Miscellaneous 2 | ETA2023

Evaluation of advanced end glycation products (AGES), their solube receptors (SRAGE) and the components of oxidative stress in patients with hashimoto’s thyroiditis on levothyroxine substitution

Csiha Sara , Molnar Istvan , Halmi Sandor , Hutkai David , Lorincz Hajnalka , Somodi Sandor , Katko Monika , Harangi Mariann , Paragh Gyorgy , Nagy Endre V. , Bodor Miklos , Berta Eszter

Background: Advanced glycation end products (AGEs) are heterogenous group of irreversible chemical moieties originated from non-enzymatic glycation and oxidation of proteins, nucleic acids, and lipids. The engagement of AGEs with their chief cellular receptor (RAGE) activates signaling pathways contributing to the progression of chronic diseases like autoimmune thyroiditis, type 2 diabetes mellitus and its complications. Soluble RAGE (sRAGE) prevents AGE-RAGE interaction in a ...

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Evaluation of advanced end glycation products (AGES), their solube receptors (SRAGE) and the components of oxidative stress in patients with hashimoto’s thyroiditis on levothyroxine substitution

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